Which of the following is NOT a consideration for substance scheduling?

The correct answer is the cultural significance of the drug. When substances are scheduled, the primary factors taken into account include the drug's potential for abuse, its accepted medical use in treatment, and the associated safety or risk of dependence. The classification of substances is largely based on scientific research and health-related criteria.

Cultural significance, while an important aspect in broader discussions about drugs, is not a formal consideration in the scheduling process. The scheduling system is meant to protect public health and safety based on empirical evidence regarding a substance's effects and risks rather than its societal or cultural implications. Therefore, this aspect does not influence the legal categorization of a drug in the same way that the other factors do.