Which drug is known for producing "reverse tolerance" or "drug sensitization"?

Reverse tolerance, also known as drug sensitization, is a phenomenon where an individual experiences increased effects of a drug with repeated use, as opposed to the more common tolerance development where greater amounts are needed to achieve the same effect. Cocaine is particularly well-documented for this phenomenon. It can lead to heightened responses in users with continued exposure, meaning that smaller amounts can produce stronger effects over time for some individuals.

This response may involve changes in the brain's dopamine system, which cocaine primarily affects, leading to increased feelings of euphoria or other effects with less drug consumption. Understanding this unique property of cocaine is crucial for recognizing its potential for addiction and the varied experiences among users with incremental exposures. It illustrates the importance of monitoring and managing drug use to prevent unintended consequences.

In contrast, heroin, oxycodone, and marijuana typically demonstrate the more familiar pattern of tolerance development rather than reverse tolerance, where users need to consume more of the substance to achieve the desired effect over time.